26 NPD measurements in subjects with borderline sweat test
نویسندگان
چکیده
منابع مشابه
Nasal potential difference in cystic fibrosis patients presenting borderline sweat test.
The diagnosis of cystic fibrosis (CF) can be difficult if the sweat test and routine deoxyribonucleic acid (DNA) analysis are inconclusive. Under these circumstances, measurement of nasal potential difference (NPD) was proposed as a complementary diagnostic tool, as demonstrated in subjects bearing the G551S or 3849+10KbC-->T mutations. The purpose of the present study was to verify the diagnos...
متن کاملDoes extensive genotyping and nasal potential difference testing clarify the diagnosis of cystic fibrosis among patients with single-organ manifestations of cystic fibrosis?
BACKGROUND The phenotypic spectrum of cystic fibrosis (CF) has expanded to include patients affected by single-organ diseases. Extensive genotyping and nasal potential difference (NPD) testing have been proposed to assist in the diagnosis of CF when sweat testing is inconclusive. However, the diagnostic yield of extensive genotyping and NPD and the concordance between NPD and the sweat test hav...
متن کاملSweat test with water-erasable ink.
© 2012 The Authors. doi: 10.2340/00015555-1300 Journal Compilation © 2012 Acta Dermato-Venereologica. ISSN 0001-5555 There are many methods for assessing abnormalities in perspiration, including practical, qualitative, and quantitative methods. Among the methods of visualizing local and generalized perspiration, the Minor, or starch-iodine, test is widely used to identify areas of excessive or ...
متن کاملFractional measurements of sweat osmolality in patients with cystic fibrosis.
After pilocarpine iontophoresis the change of sweat concentration during collection was studied by vapour pressure osmometry in 24 patients with cystic fibrosis and 24 healthy controls. There was a continuous but proportionate fall in sweat concentrations during the collection period. Mean (SD) initial sweat concentration in the control group was 154.4 (32.6) mmol/kg falling, after 50 microlite...
متن کاملTransepithelial nasal potential difference (NPD) measurements in cystic fibrosis (CF).
The main underlying physiologic abnormality in cystic fibrosis (CF) is dysfunction of the CF transmembrane conductance regulator (CFTR), which results in abnormal transport of sodium and chloride across epithelial surfaces. CFTR function could be tested in vivo using measurements of nasal transepithelial potential difference (PD). Nasal measurements show characteristic features of CF epithelia,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cystic Fibrosis
سال: 2012
ISSN: 1569-1993
DOI: 10.1016/s1569-1993(12)60195-7